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^: *https://onlinelibrary.wiley.com/loi/14390434 (https://onlinelibrary.wiley.com/loi/14390434)
^: Silva F.J.; Campos V.P.; Oliveira D.F.; Gomes V.A.; Barros A.F.; Zia Ud Din; Rodrigues-Filho E.
^: Chalcone analogues: Synthesis, activity against Meloidogyne incognita, and in silico interaction with cytochrome P450 [ Meloidogyne incognita; in silico P450. ()]
^: Journal of Phytopathology, 2019; Vol.167,N 4. - P. 197-208
^: 2019
^: Bibliogr.:p.206-208
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aref2 To contribute the development of new products to control plant-parasitic nematodes, 12 chalcone analogues were synthesized and screened for activity against Meloidogyne incognita. Three caused mortality greater than negative controls in second-stage juvenile M. incognita, with values varying from 19.9% to 100%. The most active chalcone analogue was (1E,4E)-1,5-di(4-nitrophenyl)-2-butylpenta-1,4-dien-3-one (compound 6), which had an LC50 value of 41 g/ml. Under the same conditions, the commercial nematicide Carbofuran (2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate) presented an LC50 equal to 101 g/ml. When this chalcone analogue was applied to tomato plants infested with M. incognita, reductions in the numbers of galls and eggs of 51% and 68% were observed, respectively. According to in silico studies, the enzyme target of compound 6 in M. incongita is cytochrome P450, which is important for the oxidation of several substances in the nematode. Therefore, compound 6 is potentially useful for the development of new products to control M. incongita.

^TRN: 1912559
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